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Target practice: Zic2 hits the bullseye!
Author(s) -
Wilson Sara I
Publication year - 2010
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2010.209
Subject(s) - biology , computational biology , genetics
A major challenge in biology is to unravel how neurons make appropriate functional connections. This is a multistep process that includes guiding, targeting and refinement of axons. García‐Frigola and Herrera show that the transcription factor Zic2, which governs axon guidance at the midline also regulates the subsequent axonal refinement at targets in the brain.