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Ups delivery to the intermembrane space of mitochondria: a novel affinity‐driven protein import pathway
Author(s) -
Herrmann Johannes M
Publication year - 2010
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2010.189
Subject(s) - intermembrane space , biology , microbiology and biotechnology , mitochondrial intermembrane space , mitochondrion , computational biology , biochemistry , bacterial outer membrane , gene , escherichia coli
Mitochondria are comprised of two aqueous subcompartments, the matrix and the intermembrane space (IMS). The import of proteins to the IMS is poorly understood and two studies published in this issue of the EMBO Journal provide further insight into this. Potting et al (2010) and Tamura et al (2010) show that Mdm35 is important for the mitochondrial import of Ups proteins.