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Neurons don't appreciate FUSsing in the cytoplasm
Author(s) -
Buratti Emanuele,
Baralle Francisco E
Publication year - 2010
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2010.163
Subject(s) - amyotrophic lateral sclerosis , biology , neurodegeneration , frontotemporal lobar degeneration , molecular pathology , library science , genetics , pathology , medicine , disease , frontotemporal dementia , gene , dementia , computer science
Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease, is characterized by degeneration of motor neurons. In this issue of The EMBO Journal , Dormann et al. link ALS‐associated mutations in the FUS protein with alterations in nuclear import and stress granule formation.