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Trapping Rap1 at the telomere to prevent chromosome end fusions
Author(s) -
Greenwood Jessica,
Cooper Julia Promisel
Publication year - 2009
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2009.299
Subject(s) - biology , telomere , rap1 , trapping , genetics , chromosome , microbiology and biotechnology , dna , gene , ecology
The prevention of nonhomologous end‐joining (NHEJ) reactions between chromosome ends is crucial for maintaining genome stability. Although this protective function is known to be fulfilled by a core of conserved telomeric proteins that are collectively known as Shelterin, its mechanistic details remain a mystery. In this issue, Sarthy et al (2009) lend fresh insight by developing an ingenious method to dissect the role of hRAP1 in preventing telomeric NHEJ independently of other Shelterin components.