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Regulation of Notch and Wingless signalling by phyllopod, a transcriptional target of the EGFR pathway
Author(s) -
Nagaraj Raghavendra,
Banerjee Utpal
Publication year - 2009
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2008.286
Subject(s) - biology , notch signaling pathway , microbiology and biotechnology , signalling , signal transduction , cyclin dependent kinase 8 , genetics , computational biology
Spatial and temporal control of Notch and Wingless (Wg) pathways during development is regulated at multiple levels. Here, we present an analysis of Phyllopod as a coordinated regulator of these two critical signal transduction pathways. Phyl specifically helps traffic Notch and Wg pathway components within early endocytic vesicles, thereby controlling the amount of processed signal available for causing a transcriptional response within the nucleus. In Drosophila , the EGFR pathway transcriptionally activates phyl whose product then blocks Notch and Wg signalling pathways. This provides a mechanistic basis for an antagonistic relationship between receptor tyrosine kinase and Notch/Wg pathways during development. Furthermore, this study identifies a Phyl‐regulated class of endosomal vesicles that specifically include components of Notch and Wg signalling.

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