Primate autoimmune disease models; lost for translation? | Zendy

't Hart Bert A | Zendy

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Primate autoimmune disease models; lost for translation?

Author(s) -

't Hart Bert A

Publication year - 2016

Publication title -

clinical and translational immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.321

H-Index - 34

ISSN - 2050-0068

DOI - 10.1038/cti.2016.82

Subject(s) - experimental autoimmune encephalomyelitis , multiple sclerosis , impossibility , primate , nonhuman primate , translation (biology) , disease , autoimmune disease , non human primate , neuroscience , computational biology , medicine , biology , computer science , immunology , genetics , evolutionary biology , political science , pathology , gene , messenger rna , law

Replacement, reduction and refinement (the 3R's) are the leading principles in translational research with animals. To be useful a model should also be clinically Relevant (the 4th R). Work in a non‐human primate model of multiple sclerosis, the experimental autoimmune encephalomyelitis model, reveals an inherent conflict among these 4R principles. The impossibility to harmonize all 4R's forms a major challenge when the model is applied in preclinical drug development.

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