Open AccessThe immunological effect of hyaluronan in tumor angiogenesis
Author(s) -
Spinelli Fiorella M,
Vitale Daiana L,
Demarchi Gianina,
Cristina Carolina,
Alaniz Laura
Publication year - 2015
Publication title -
clinical and translational immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.321
H-Index - 34
ISSN - 2050-0068
DOI - 10.1038/cti.2015.35
Subject(s) - angiogenesis , immune system , extracellular matrix , neovascularization , tumor microenvironment , cancer research , microbiology and biotechnology , biology , immunology
The relationship between the immune system and angiogenesis has been described in several contexts, both in physiological and pathological conditions, as pregnancy and cancer. In fact, different types of immune cells, such as myeloid, macrophages and denditric cells, are able to modulate tumor neovascularization. On the other hand, tumor microenvironment also includes extracellular matrix components like hyaluronan, which has a deregulated synthesis in different tumors. Hyaluronan is a glycosaminoglycan, normally present in the extracellular matrix of tissues in continuous remodeling (embryogenesis or wound healing processes) and acts as an important modulator of cell behavior by different mechanisms, including angiogenesis. In this review, we discuss hyaluronan as a modulator of tumor angiogenesis, focusing in intracellular signaling mediated by its receptors expressed on different immune cells. Recent observations suggest that the immune system is an important component in tumoural angiogenesis. Therefore, immune modulation could have an impact in anti‐angiogenic therapy as a new therapeutic strategy, which in turn might improve effectiveness of treatment in cancer patients.