Open AccessAccelerating immune reconstitution after hematopoietic stem cell transplantation
Author(s) -
Tzannou Ifigeneia,
Leen Ann M
Publication year - 2014
Publication title -
clinical and translational immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.321
H-Index - 34
ISSN - 2050-0068
DOI - 10.1038/cti.2014.2
Subject(s) - immune system , hematopoietic stem cell transplantation , stem cell , transplantation , adoptive cell transfer , immunology , haematopoiesis , hematopoietic stem cell , hematopoietic cell , medicine , biology , t cell , genetics
Viral infections remain a significant cause of morbidity and mortality after hematopoietic stem cell transplantation. Pharmacologic agents are effective against some pathogens, but they are costly and can be associated with significant toxicities. Thus, many groups have investigated adoptive T‐cell transfer as a means of hastening immune reconstitution and preventing and treating viral infections. This review discusses the immunotherapeutic strategies that have been explored.