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Association of CHRNA5‐A3‐B4 SNP rs2036527 With Smoking Cessation Therapy Response in African‐American Smokers
Author(s) -
Zhu A Z X,
Zhou Q,
Cox L S,
David S P,
Ahluwalia J S,
Benowitz N L,
Tyndale R F
Publication year - 2014
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2014.88
Subject(s) - abstinence , smoking cessation , medicine , bupropion , nicotine , odds ratio , pharmacotherapy , snp , genotype , psychiatry , single nucleotide polymorphism , genetics , biology , pathology , gene
Associations between CHRNA5‐A3‐B4 variants and smoking behaviors exist; however, the association with smoking abstinence is less understood, particularly that among African Americans. In 1,295 African Americans enrolled in two clinical trials, we investigated the association between CHRNA5‐A3‐B4 and smoking abstinence. The rs2056527(A) allele was associated with lower abstinence with active pharmacotherapy (during treatment: odds ratio (OR) = 0.42, P < 0.001; end of treatment (EOT): OR = 0.55, P = 0.004), or with nicotine gum alone (during treatment: OR = 0.31, P < 0.001; EOT: OR = 0.51, P = 0.02), but not significantly with bupropion, although similar directions and magnitudes were observed (during treatment: OR = 0.54, P = 0.05; EOT: OR = 0.59, P = 0.08). In addition, the rs588765(T) allele was associated with abstinence with gum during treatment (OR = 2.31, P < 0.01). The SNP rs16969968 occurred at a low frequency and was not consistently associated with abstinence. CHRNA5‐A3‐B4 variants were not associated with tobacco consumption, and adjustments for smoking behaviors did not alter the associations with smoking abstinence. Together, our data suggest that among African Americans, CHRNA5‐A3‐B4 variants are not associated with baseline smoking but can influence smoking abstinence during active pharmacotherapy. Clinical Pharmacology & Therapeutics (2014); 96 2, 256–265. doi: 10.1038/clpt.2014.88