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The Ebbs and Flows in the Development of Cholesterol‐Lowering Drugs: Prospects for the Future
Author(s) -
Hajhosseiny R,
Sabir I,
Khavandi K,
Wierzbicki A S
Publication year - 2014
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2014.76
Subject(s) - clinical pharmacology , medicine , cholesterol , pharmacology , intensive care medicine
Cardiovascular disease (CVD) is the leading cause of mortality worldwide, and its prevalence is increasing worldwide. Statins are the mainstay of treatment but do not address all aspects of CVD risk. Other lipid‐lowering therapies are available but are less effective than statins. New therapies to lower low‐density‐lipoprotein cholesterol (LDL‐C) by as much as statins, to reduce triglycerides (TGs), and to modify the metabolism of high‐density lipoproteins (HDLs) are in development. Clinical Pharmacology & Therapeutics (2014); 96 1, 64–73. doi: 10.1038/clpt.2014.76