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Optimizing Dosing of Oncology Drugs
Author(s) -
Minasian L,
Rosen O,
Auclair D,
Rahman A,
Pazdur R,
Schilsky R L
Publication year - 2014
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2014.153
Subject(s) - dosing , clinical pharmacology , medicine , pharmacology , clinical oncology , drug , drug development , intensive care medicine , precision oncology , cancer
The purpose of this article is to acknowledge the challenges in optimizing the dosing of oncology drugs and to propose potential approaches to address these challenges in order to optimize effectiveness, minimize toxicity, and promote adherence in patients. These approaches could provide better opportunities to understand the sources of variability in drug exposure and clinical outcomes during the development and premarketing evaluation of investigational new drugs. Clinical Pharmacology & Therapeutics (2014); 96 5, 572–579. doi: 10.1038/clpt.2014.153