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A Snapshot of Challenges and Solutions in Cancer Drug Development and Therapy
Author(s) -
Phelps M A,
Sparreboom A
Publication year - 2014
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2014.15
Subject(s) - clinical pharmacology , snapshot (computer storage) , cancer therapy , medicine , drug , cancer chemotherapy , modalities , drug development , clinical oncology , cancer treatment , pharmacology , cancer , intensive care medicine , oncology , computer science , social science , sociology , operating system
Cancer chemotherapy has transitioned from the use of cytotoxic drugs to the era of agents with an apparent selectivity for a cancer‐specific target. The past decade has provided evidence that therapy with such agents can be curative in subsets of patients. It is anticipated that incorporation of pharmacological principles for novel therapeutics will result in further refinement of outcome measures as well as the discovery of new treatment modalities for multiple malignant diseases. Clinical Pharmacology & Therapeutics (2014); 95 4, 341–346. doi: 10.1038/clpt.2014.15