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Longitudinal Inflammation, Cognitive Decline, and Alzheimer's Disease: A Mini‐Review
Author(s) -
Bettcher B M,
Kramer J H
Publication year - 2014
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2014.147
Subject(s) - cognitive decline , inflammation , cognition , disease , medicine , alzheimer's disease , longitudinal study , dementia , psychology , immunology , psychiatry , pathology
The role of inflammation in cognitive decline has generated considerable interest, although few longitudinal evaluations have been conducted. A review of the literature yields mixed findings but suggests that inflammatory dysregulation is evident and may be related to clinical outcomes. The directionality, magnitude, and progression of these associations remain unclear. Future studies employing multiple time points of inflammatory data along with Alzheimer's disease (AD) biomarkers are critical for explication of longitudinal inflammation in cognitive decline. Clinical Pharmacology & Therapeutics (2014); 96 4, 464–469. doi: 10.1038/clpt.2014.147