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Antipsychotics and Associated Risk of Out‐of‐Hospital Cardiac Arrest
Author(s) -
Weeke P,
Jensen A,
Folke F,
Gislason G H,
Olesen J B,
Fosbøl E L,
Wissenberg M,
Lippert F K,
Christensen E F,
Nielsen S L,
Holm E,
Kanters J K,
Poulsen H E,
Køber L,
TorpPedersen C
Publication year - 2014
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2014.139
Subject(s) - medicine , antipsychotic , levomepromazine , quetiapine , odds ratio , atypical antipsychotic , olanzapine , risperidone , haloperidol , pharmacology , schizophrenia (object oriented programming) , psychiatry , dopamine
Antipsychotic drugs have been associated with sudden cardiac death, but differences in the risk of out–of–hospital cardiac arrest (OHCA) associated with different antipsychotic drug classes are not clear. We identified all OHCAs in Denmark (2001–2010). The risk of OHCA associated with antipsychotic drug use was evaluated by conditional logistic regression analysis in case–time–control models. In total, 2,205 (7.6%) of 28,947 OHCA patients received treatment with an antipsychotic drug at the time of the event. Overall, treatment with any antipsychotic drug was associated with OHCA (odds ratio (OR) = 1.53, 95% confidence interval (CI): 1.23–1.89), as was use with typical antipsychotics (OR = 1.66, CI: 1.27–2.17). By contrast, overall, atypical antipsychotic drug use was not (OR = 1.29, CI: 0.90–1.85). Two individual typical antipsychotic drugs, haloperidol (OR = 2.43, CI: 1.20–4.93) and levomepromazine (OR = 2.05, CI: 1.18–3.56), were associated with OHCA, as was one atypical antipsychotic drug, quetiapine (OR = 3.64, CI: 1.59–8.30). Clinical Pharmacology & Therapeutics (2014); 96 4, 490–497. doi: 10.1038/clpt.2014.139