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Pharmacogenetics in the Cancer Clinic: From Candidate Gene Studies to Next‐Generation Sequencing
Author(s) -
Guchelaar HJ,
Gelderblom H,
Straaten T,
Schellens JHM,
Swen JJ
Publication year - 2014
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2014.13
Subject(s) - pharmacogenetics , drug response , clinical pharmacology , candidate gene , drug , medicine , computational biology , biology , gene , pharmacology , genetics , bioinformatics , genotype
Genetics has significantly added to our understanding of variability in drug response, especially in cancer treatment. Pharmacogenetics, aimed at predicting a patient's chance for effective and safe drug treatment by interrogating germ line genetic variants, has moved from investigating a monogenetic candidate gene to examining complex phenotype‐based genome‐wide approaches. With the rapid advances in sequencing technologies, decline in costs, and swift turnaround times, large‐scale genomic information will become available in the clinical setting, facilitating implementation of pharmacogenetics. Clinical Pharmacology & Therapeutics (2014); 95 4, 383–385. doi: 10.1038/clpt.2014.13