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Functional Gene Variants of CYP3A4
Author(s) -
Werk A N,
Cascorbi I
Publication year - 2014
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2014.129
Subject(s) - cyp3a4 , cytochrome p450 , biology , allele , gene , genetics , isozyme , clinical significance , cyp2d6 , computational biology , enzyme , medicine , biochemistry
Cytochrome P450 3A4 (CYP3A4) is involved in the metabolism of more drugs in clinical use than any other foreign compound–metabolizing enzyme in humans. Recently, increasing evidence has been found showing that variants in the CYP3A4 gene have functional significance and—in rare cases—lead to loss of activity, implying tremendous consequences for patients. This review article highlights the functional consequences of all CYP3A4 variants recognized by the Human Cytochrome P450 (CYP) Allele Nomenclature Database. Clinical Pharmacology & Therapeutics (2014); 96 3, 340–348. advance online publication 16 July 2014. doi: 10.1038/clpt.2014.129