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Pharmacogenomics of Human Uridine Diphospho‐Glucuronosyltransferases and Clinical Implications
Author(s) -
Guillemette C,
Lévesque É,
Rouleau M
Publication year - 2014
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2014.126
Subject(s) - glucuronidation , glucuronosyltransferase , uridine , pharmacogenomics , clinical pharmacology , uridine diphosphate , pharmacology , drug metabolism , xenobiotic , pharmacogenetics , drug , chemistry , computational biology , enzyme , biochemistry , biology , rna , gene , microsome , genotype
Glucuronidation by uridine diphospho‐glucuronosyltransferase enzymes (UGTs) is a major phase II biotransformation pathway and, complementary to phase I metabolism and membrane transport, one of the most important cellular defense mechanisms responsible for the inactivation of therapeutic drugs, other xenobiotics, and endogenous molecules. Interindividual variability in UGT pathways is significant and may have profound pharmacological and toxicological implications. Several genetic and genomic processes underlie this variability and are discussed in relation to drug metabolism and diseases such as cancer. Clinical Pharmacology & Therapeutics (2014); 96 3, 324–339. advance online publication 16 July 2014. doi: 10.1038/clpt.2014.126