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The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1 and Simvastatin‐Induced Myopathy: 2014 Update
Author(s) -
Ramsey L B,
Johnson S G,
Caudle K E,
Haidar C E,
Voora D,
Wilke R A,
Maxwell W D,
McLeod H L,
Krauss R M,
Roden D M,
Feng Q,
CooperDeHoff R M,
Gong L,
Klein T E,
Wadelius M,
Niemi M
Publication year - 2014
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2014.125
Subject(s) - slco1b1 , simvastatin , pharmacogenetics , myopathy , guideline , medicine , statin , single nucleotide polymorphism , pharmacology , medical prescription , genotype , bioinformatics , biology , genetics , pathology , gene
Simvastatin is among the most commonly used prescription medications for cholesterol reduction. A single coding single‐nucleotide polymorphism, rs4149056T>C, in SLCO1B1 increases systemic exposure to simvastatin and the risk of muscle toxicity. We summarize evidence from the literature supporting this association and provide therapeutic recommendations for simvastatin based on SLCO1B1 genotype. This article is an update to the 2012 Clinical Pharmacogenetics Implementation Consortium guideline for SLCO1B1 and simvastatin‐induced myopathy. Clinical Pharmacology & Therapeutics (2014); 96 4, 423–428. doi: 10.1038/clpt.2014.125