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Transporters in Drug Development and Clinical Pharmacology
Author(s) -
Giacomini K M,
Huang SM
Publication year - 2013
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2013.86
Subject(s) - clinical pharmacology , transporter , pharmacology , drug , atp binding cassette transporter , pharmacokinetics , solute carrier family , distribution (mathematics) , drug metabolism , drug development , medicine , biology , chemistry , biochemistry , gene , mathematical analysis , mathematics
More than 400 membrane transporters in two major superfamilies—ATP‐binding cassette (ABC) and solute carrier (SLC)—are annotated in the human genome. Preclinical and clinical studies indicate that transport is an important determinant of drug disposition, as well as therapeutic and adverse drug effects. Importantly, transporters may represent the rate‐determining step of drug absorption, distribution, and elimination in the intestine, liver, kidney, and blood–brain barrier (BBB), and they are often the sites of drug–drug interactions. Clinical Pharmacology & Therapeutics (2013); 94 1, 3–9. doi: 10.1038/clpt.2013.86