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Imaging in the Study of Membrane Transporters
Author(s) -
Kusuhara H
Publication year - 2013
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2013.85
Subject(s) - pharmacogenomics , transporter , clinical pharmacology , pharmacology , pharmacokinetics , distribution (mathematics) , drug , tissue distribution , medicine , computational biology , chemistry , biology , biochemistry , mathematical analysis , mathematics , gene
Pharmacokinetic analysis involving the measurement of tissue distribution of drugs contributes to better understanding of the clearance and distribution mechanisms of drugs, drug–drug interaction mechanisms, and the pharmacogenomics of transporters, as well as of the efficacy of drugs designed to modulate transport activities. Transporter imaging study, which involves the noninvasive measurement of tissue distributions of drugs, is an evolving field. Focusing on clinical data, this article highlights the application of imaging studies in membrane transporters. Clinical Pharmacology & Therapeutics (2013); 94 1, 33–36. doi: 10.1038/clpt.2013.85