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SLC Classification: An Update
Author(s) -
Schlessinger A,
Yee S W,
Sali A,
Giacomini K M
Publication year - 2013
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2013.73
Subject(s) - superfamily , computational biology , identification (biology) , sequence (biology) , similarity (geometry) , function (biology) , bioinformatics , clinical pharmacology , biology , genetics , computer science , artificial intelligence , gene , botany , image (mathematics)
The 386 human SLC superfamily members are diverse in sequence, structure, and function. Using sequence similarity, we previously classified the SLC superfamily members and identified relationships among families. With the recent determination of new SLC structures and identification of previously unknown human SLC families, an update of our previous classification is timely. Here, we comprehensively compare the SLC sequences and structures and discuss the applicability of structure‐based ligand discovery to key SLC members. Clinical Pharmacology & Therapeutics (2013); 94 1, 19–23. doi: 10.1038/clpt.2013.73