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ITC Recommendations for Transporter Kinetic Parameter Estimation and Translational Modeling of Transport‐Mediated PK and DDIs in Humans
Author(s) -
ZamekGliszczynski M J,
Lee C A,
Poirier A,
Bentz J,
Chu X,
Ellens H,
Ishikawa T,
Jamei M,
Kalvass J C,
Nagar S,
Pang K S,
Korzekwa K,
Swaan P W,
Taub M E,
Zhao P,
Galetin A
Publication year - 2013
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2013.45
Subject(s) - transporter , pharmacology , computational biology , pharmacokinetics , clinical pharmacology , in vivo , drug , computer science , chemistry , medicine , biology , biochemistry , gene , microbiology and biotechnology
This white paper provides a critical analysis of methods for estimating transporter kinetics and recommendations on proper parameter calculation in various experimental systems. Rational interpretation of transporter‐knockout animal findings and application of static and dynamic physiologically based modeling approaches for prediction of human transporter‐mediated pharmacokinetics and drug–drug interactions (DDIs) are presented. The objective is to provide appropriate guidance for the use of in vitro , in vivo , and modeling tools in translational transporter science. Clinical Pharmacology & Therapeutics (2013); 94 1, 64–79. doi: 10.1038/clpt.2013.45