Premium
Pharmacogenomics in Psychiatry: From Therapeutic Drug Monitoring to Genomic Medicine
Author(s) -
Crettol S,
Leon J,
Hiemke C,
Eap C B
Publication year - 2014
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2013.221
Subject(s) - pharmacogenomics , therapeutic drug monitoring , pharmacotherapy , medicine , precision medicine , drug , drug response , nice , medline , psychiatry , intensive care medicine , pharmacology , computer science , biology , pathology , programming language , biochemistry
Psychiatry is increasingly combining new pharmacogenomic findings with therapeutic drug monitoring (TDM) to improve the safety and efficacy of pharmacotherapy. However, a distinction should be made between “nice to know” and “need to know” pharmacogenomic data because many results are statistically significant in meta‐analyses but are not clinically relevant due to their low effect sizes. Some examples will illustrate this integration.