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Systems‐Based Discovery Advances Drug Development
Author(s) -
Waldman S A,
Terzic A
Publication year - 2013
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2013.21
Subject(s) - drug discovery , informatics , clinical pharmacology , systems pharmacology , computational biology , drug , systems biology , computer science , drug development , data science , pharmacology , biology , bioinformatics , engineering , electrical engineering
Drug development expenditures continue to escalate, in part reflecting inefficiencies in current drug discovery paradigms. Traditional drug discovery has been dichotomous, focusing either on phenotypic effects of distinct agents in biological systems, without knowledge of respective targets, or on target‐based activities of specific molecules in cell‐free assays. Driven by advances in biology, engineering, and informatics, new paradigms integrate phenotypic with target‐based algorithms into comprehensive, systems‐level approaches offering value‐added strategies for optimized drug discovery. Clinical Pharmacology & Therapeutics (2013); 93 4, 285–287. doi: 10.1038/clpt.2013.21