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Network Medicine in Disease Analysis and Therapeutics
Author(s) -
Chen B,
Butte A J
Publication year - 2013
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2013.181
Subject(s) - drug discovery , disease , precision medicine , computational biology , medicine , data science , computer science , bioinformatics , biology , pathology
Two parallel trends are occurring in drug discovery. The first is that we are moving away from a symptom‐based disease classification system to a system based on molecules and molecular states. The second is that we are shifting from targeting a single molecule toward targeting multiple molecules, pathways, or networks. Network medicine is an approach to understanding disease and discovering therapeutics looking at many molecules and how they interrelate, and it may play a critical role in the adoption of both trends. Clinical Pharmacology & Therapeutics (2013); 94 6, 627–629. doi: 10.1038/clpt.2013.181