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Profiling Solute Carrier Transporters in the Human Blood–Brain Barrier
Author(s) -
Geier E G,
Chen E C,
Webb A,
Papp A C,
Yee S W,
Sadee W,
Giacomini K M
Publication year - 2013
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2013.175
Subject(s) - transporter , blood–brain barrier , solute carrier family , atp binding cassette transporter , pharmacology , organic anion transporter 1 , drug , biology , central nervous system , neuroprotection , efflux , chemistry , biochemistry , neuroscience , gene
The neuroprotective function of the blood–brain barrier (BBB) presents a major challenge for drug delivery to the central nervous system (CNS). Critical to this function, BBB membrane transporters include the ATP‐binding cassette (ABC) transporters, which limit drug penetration across the BBB, and the less‐well‐studied solute carrier (SLC) transporters. In this work, expression profiling of 359 SLC transporters, comparative expression analysis with kidney and liver, and immunoassays in brain microvessels (BMVs) identified previously unknown transporters at the human BBB. Clinical Pharmacology & Therapeutics (2013); 94 6, 636–639. doi: 10.1038/clpt.2013.175