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Metabolic Phenotyping of Diabetic Nephropathy
Author(s) -
Mäkinen VP,
Kangas A J,
Soininen P,
Würtz P,
Groop PH,
AlaKorpela M
Publication year - 2013
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2013.158
Subject(s) - medicine , nephropathy , diabetic nephropathy , diabetes mellitus , type 2 diabetes , complication , intensive care medicine , kidney , urology , bioinformatics , endocrinology , biology
Diabetic nephropathy is the most serious complication of type 1 diabetes. There is no treatment to protect the kidneys from poorly controlled diabetes, and therefore prevention of the initial metabolic insults is currently the only effective approach to reducing the high mortality related to diabetic nephropathy. Metabolic phenotyping brings us one step closer to understanding the unique set of regulatory perturbations that predispose to kidney injury and paves the way for multiparametric risk assessment. Clinical Pharmacology & Therapeutics (2013); 94 5, 566–569. doi: 10.1038/clpt.2013.158