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Genetics of Cisplatin Ototoxicity: Confirming the Unexplained?
Author(s) -
Boddy A V
Publication year - 2013
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2013.116
Subject(s) - ototoxicity , clinical pharmacology , pharmacogenetics , thiopurine methyltransferase , cisplatin , pharmacology , medicine , genotype , pharmacogenomics , biology , genetics , chemotherapy , inflammatory bowel disease , disease , gene
Replication of findings in clinical pharmacogenetic studies is essential but often neglected. The observation that TPMT and COMT genotypes, in combination with ABCC3 genotype, are predictive of ototoxicity following cisplatin treatment has been confirmed. However, translating this observation into a useful preventive strategy requires more mechanistic insight. Clinical Pharmacology & Therapeutics (2013); 94 2, 198–200. doi: 10.1038/clpt.2013.116