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Challenges in the Pharmacogenomic Annotation of Whole Genomes
Author(s) -
Altman R B,
WhirlCarrillo M,
Klein T E
Publication year - 2013
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2013.111
Subject(s) - pharmacogenomics , clinical pharmacology , computational biology , annotation , genome , whole genome sequencing , pharmacogenetics , dna sequencing , human genome , genome project , personalized medicine , biology , pharmacology , genetics , gene , genotype
Next‐generation sequencing technologies have enabled the sequencing of an entire genome for less than $4,000. With access to all the genetic variation in an individual, our task will be to use this information to assess the genetic influences on drug efficacy, toxicity, and dosage. Clinical Pharmacology & Therapeutics (2013); 94 2, 211–213. doi: 10.1038/clpt.2013.111