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Are Drug Labels Static or Dynamic?
Author(s) -
Seminerio M J,
Ratain M J
Publication year - 2013
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2013.109
Subject(s) - drug , clinical pharmacology , pharmacology , pharmacokinetics , drug metabolism , food and drug administration , medicine , drug administration , computer science
Understanding drug metabolism is essential for identifying drug–drug interactions (DDIs). As new data concerning a drug's pharmacokinetics arise, updates to drug labels and administration procedures should rapidly follow. However, the US Food and Drug Administration (FDA) has inconsistently updated drug labels, based on new research findings (i.e., in peer‐reviewed publications). In this Commentary, we highlight recent findings on the metabolism of imatinib and argue for a more stringent protocol for updating drug labels. Clinical Pharmacology & Therapeutics (2013); 94 3, 302–304. doi: 10.1038/clpt.2013.109