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Needs for an Expanded Ontology‐Based Classification of Adverse Drug Reactions and Related Mechanisms
Author(s) -
Zhichkin P E,
Athey B D,
Avigan M I,
Abernethy D R
Publication year - 2012
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2012.41
Subject(s) - ontology , clinical pharmacology , drug reaction , vocabulary , drug , computer science , adverse drug reaction , adverse effect , medicine , pharmacology , data science , epistemology , philosophy , linguistics
The growing significance of bioinformatics and systems biology in drug safety research requires a system of adverse‐event classification that goes beyond a simple vocabulary. This opinion piece outlines the need for development of an ontology‐based framework of describing adverse drug reactions (ADRs) and describes the potential applications for such a framework. Clinical Pharmacology & Therapeutics (2012); 91 6, 963–965. doi: 10.1038/clpt.2012.41