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Developing New Drug Treatments in the Era of Network Medicine
Author(s) -
Silverman E K,
Loscalzo J
Publication year - 2013
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2012.207
Subject(s) - clinical pharmacology , drug development , systems pharmacology , medicine , drug , pharmacology , disease , intensive care medicine , personalized medicine , bioinformatics , biology
Although impressive advances have been made in determining the genetic and molecular causes of disease, treatment for many complex diseases remains inadequate. Despite compelling unmet medical needs and new insights into disease pathobiology, new drug approvals for complex diseases have stagnated. A new paradigm for drug development is needed, and key concepts from network medicine and systems pharmacology may be essential to this effort. Clinical Pharmacology & Therapeutics (2013); 93 1, 26–28. doi: 10.1038/clpt.2012.207