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Longitudinal Cystic Fibrosis Care
Author(s) -
Antunovic S S,
Lukac M,
Vujovic D
Publication year - 2013
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2012.183
Subject(s) - cystic fibrosis , medicine , cystic fibrosis transmembrane conductance regulator , intensive care medicine , disease , life expectancy , psychological intervention , regimen , bioinformatics , biology , nursing , population , environmental health
Cystic fibrosis is a complex disease entity that presents considerable lifelong challenges. Implementation of medical and surgical treatment options involves multisystem interventions to prevent and treat lung and gastrointestinal manifestations of cystic fibrosis and associated comorbidities. From birth through adulthood, cystic fibrosis care entails a longitudinal regimen aimed at achieving relief of disease symptoms and enhanced life expectancy. With increased knowledge of the molecular behavior of the cystic fibrosis transmembrane conductance regulator (CFTR) in health and disease, clinical practice has been enriched by the prospect of novel strategies, including mutation‐specific drug and gene therapy targeting restoration of corrupted transepithelial ion transport. Emerging paradigms of comprehensive care increasingly enable personalized solutions to address the root cause of disease‐transforming management options for individuals with cystic fibrosis. Clinical Pharmacology & Therapeutics (2013); 93 1, 86–97. doi: 10.1038/clpt.2012.183