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Epigenetics: A New Link Toward Understanding Human Disease and Drug Response
Author(s) -
Cressman A M,
PiquetteMiller M
Publication year - 2012
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2012.179
Subject(s) - epigenomics , epigenetics , clinical pharmacology , human disease , computational biology , drug response , human health , genomics , phenotype , biology , drug , pharmacology , genetics , gene , medicine , genome , gene expression , dna methylation , environmental health
Molecular medicine is moving beyond genomics to encompass the new scientific field of epigenetics. First described as a conceptual model of how genes might interact with their surroundings to produce a phenotype, epigenomic research currently investigates mechanisms of nongenetic modification contributing to gene regulation and examines the impact of these changes on human health and behavior. Clinical Pharmacology & Therapeutics (2012); 92 6, 669–673. doi: 10.1038/clpt.2012.179