Premium
Zebrafish as a Model to Study Drug Transporters at the Blood–Brain Barrier
Author(s) -
Umans R A,
Taylor M R
Publication year - 2012
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2012.168
Subject(s) - zebrafish , blood–brain barrier , danio , drug , transporter , central nervous system , pharmacology , neuroscience , drug discovery , drug delivery , computational biology , chemistry , medicine , biology , bioinformatics , biochemistry , organic chemistry , gene
The blood–brain barrier (BBB) restricts the delivery of therapeutics into the central nervous system (CNS). This limitation is due largely to localization of drug transport mechanisms to the brain endothelial cells (BECs). Although mammalian and in vitro models are currently used to study drug transport, zebrafish ( Danio rerio ) are advantageous for dissecting complex biological problems such as the BBB. This report focuses on zebrafish as a suitable model system for studying the BBB and drug transport. Clinical Pharmacology & Therapeutics (2012); 92 5, 567–570. doi: 10.1038/clpt.2012.168