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A Step Closer to Personalized Chemotherapy: Consideration of the Influence of Genetic Variation in Hepatic Uptake Transporters on the Metabolism of CYP3A Substrates
Author(s) -
Benet L Z
Publication year - 2012
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2012.165
Subject(s) - transporter , clinical pharmacology , drug metabolism , pharmacology , drug , pharmacogenetics , cyp3a , metabolism , chemotherapy , pharmacogenomics , biology , medicine , computational biology , gene , genetics , biochemistry , cytochrome p450 , genotype
Understanding the metabolic, transporter, and genetic influences on the disposition of drugs used in chemotherapy is critical to individualization of drug therapy. Recognition of the importance of transporter–enzyme interplay, in which genetic variants of drug uptake transporters can change drug metabolism when the enzymes are unchanged, is an important advance in predicting appropriate drug dosage regimens for the individual patient. Clinical Pharmacology & Therapeutics (2012); 92 5, 551–552. doi: 10.1038/clpt.2012.165