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Fruit Juices as Perpetrators of Drug Interactions: The Role of Organic Anion–Transporting Polypeptides
Author(s) -
Dolton M J,
Roufogalis B D,
McLachlan A J
Publication year - 2012
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2012.159
Subject(s) - grapefruit juice , bioavailability , transporter , drug , chemistry , pharmacology , cyp3a4 , organic anion transporting polypeptide , organic cation transport proteins , fruit juice , clinical pharmacology , pharmacokinetics , biochemistry , food science , metabolism , medicine , gene , cytochrome p450
Grapefruit juice is widely recognized to cause important drug interactions via inhibition of CYP3A4, and a wider variety of fruit juices have been shown to inhibit influx transporters in enterocytes known as organic anion–transporting polypeptides (OATPs). Fruit juice coadministration significantly reduces the oral bioavailability of numerous important medicines relying on this anion transporter pathway for absorption. This article reviews the current literature on interactions between clinically used OATP substrates and fruit juice consumption. Clinical Pharmacology & Therapeutics (2012); 92 5, 622–630. doi: 10.1038/clpt.2012.159