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Epigenetic Chemical Probes
Author(s) -
Müller S,
Brown P J
Publication year - 2012
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2012.154
Subject(s) - epigenetics , histone , dna methylation , gene expression , computational biology , methylation , regulation of gene expression , biology , dna , gene , genetics
Epigenetic control of gene expression occurs at two distinct levels: DNA methylation and histone modification. Over the past 10 years, the discovery of epigenetic targets has accelerated to the point where more than 400 domains have been identified that are involved in either DNA methylation, the modification of histones (and some nonhistones), or translation of these modifications into changes in gene expression. Clinical Pharmacology & Therapeutics (2012); 92 6, 689–693. doi: 10.1038/clpt.2012.154