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Prediction of Transporter‐Mediated Drug–Drug Interactions Using Endogenous Compounds
Author(s) -
Fromm M F
Publication year - 2012
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2012.145
Subject(s) - drug , transporter , pharmacology , clinical pharmacology , drug metabolism , mechanism (biology) , drug interaction , endogeny , drug drug interaction , medicine , chemistry , biochemistry , philosophy , epistemology , gene
Therapy with two or more drugs is more the rule than the exception, particularly in aging societies. Drug–drug interactions are frequently undesirable and may lead to increased toxicity and mortality. Inhibition of transporters is one major mechanism underlying drug–drug interactions. The myriad of potential drug combinations makes it very challenging to predict drug–drug interactions. This Commentary discusses potential advantages and limitations of endogenous compounds for predicting transporter‐mediated drug–drug interactions. Clinical Pharmacology & Therapeutics (2012); 92 5, 546–548. doi: 10.1038/clpt.2012.145