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Contribution of the OATP1B Subfamily to Cancer Biology and Treatment
Author(s) -
Sissung T M,
Reece K M,
Spencer S,
Figg W D
Publication year - 2012
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2012.127
Subject(s) - subfamily , transporter , organic anion transporter 1 , clinical pharmacology , organic anion transporting polypeptide , solute carrier family , pharmacotherapy , pharmacology , homeostasis , biology , cancer , cancer therapy , medicine , biochemistry , endocrinology , gene
The organic anion transporter 1B (OATP1B) subfamily consists of OATP1B1 and OATP1B3. 1 These transporters have generally been considered liver‐specific; however, recent evidence demonstrates that they are also expressed in extrahepatic tissues and in some tumors. This review discusses the potential influence of extrahepatic OATP1B expression on homeostasis and pathophysiology and its implications for pharmacotherapy in general. Clinical Pharmacology & Therapeutics (2012); 92 5, 658–660. doi: 10.1038/clpt.2012.127