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Implementing Personalized Medicine: Development of a Cost‐Effective Customized Pharmacogenetics Genotyping Array
Author(s) -
Johnson J A,
Burkley B M,
Langaee T Y,
ClareSalzler M J,
Klein T E,
Altman R B
Publication year - 2012
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2012.125
Subject(s) - pharmacogenetics , pharmacogenomics , personalized medicine , clinical pharmacology , precision medicine , genotyping , medicine , computational biology , drug development , pharmacology , computer science , bioinformatics , medical physics , drug , biology , genotype , genetics , gene , pathology
Although there is increasing evidence to support the implementation of pharmacogenetics in certain clinical scenarios, the adoption of this approach has been limited. The advent of preemptive and inexpensive testing of critical pharmacogenetic variants may overcome barriers to adoption. We describe the design of a customized array built for the personalized‐medicine programs of the University of Florida and Stanford University. We selected key variants for the array using the clinical annotations of the Pharmacogenomics Knowledgebase (PharmGKB), and we included variants in drug metabolism and transporter genes along with other pharmacogenetically important variants. Clinical Pharmacology & Therapeutics (2012); 92 4, 437–439. doi: 10.1038/clpt.2012.125