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Pharmacogenomics and Individualized Medicine: Translating Science Into Practice
Author(s) -
Crews K R,
Hicks J K,
Pui CH,
Relling M V,
Evans W E
Publication year - 2012
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2012.120
Subject(s) - pharmacogenomics , clinical trial , personalized medicine , medicine , drug response , clinical pharmacology , clinical practice , precision medicine , translational research , bioinformatics , pharmacology , drug , biology , family medicine , pathology
Research on genes and medications has advanced our understanding of the genetic basis of individual drug responses. The aim of pharmacogenomics is to develop strategies for individualizing therapy for patients, in order to optimize outcome through knowledge of the variability of the human genome and its influence on drug response. Pharmacogenomics research is translational in nature and ranges from discovery of genotype–phenotype relationships to clinical trials that can provide proof of clinical impact. Advances in pharmacogenomics offer significant potential for subsequent clinical application in individual patients; however, the translation of pharmacogenomics research findings into clinical practice has been slow. Key components to successful clinical implementation of pharmacogenomics will include consistent interpretation of pharmacogenomics test results, availability of clinical guidelines for prescribing on the basis of test results, and knowledge‐based decision support systems. Clinical Pharmacology & Therapeutics (2012); 92 4, 467–475. doi: 10.1038/clpt.2012.120