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Strategies for Personalized Medicine–Based Research and Implementation in the Clinical Workflow
Author(s) -
Lieb W,
Völzke H,
Pulley J M,
Roden D M,
Kroemer H K
Publication year - 2012
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2012.119
Subject(s) - workflow , clinical pharmacology , personalized medicine , computational biology , computer science , drug development , data science , human genome , bioinformatics , medicine , pharmacology , drug , genome , biology , database , genetics , gene
The decoding of the human genome, paralleled by the development of high‐throughput technologies to obtain large‐scale molecular data (e.g., information on genetic variations, transcription levels, and metabolite concentrations) is providing new insights into the molecular basis of common diseases and the causes of variability in drug response. This article presents strategies to incorporate this new knowledge into research and clinical workflow. Clinical Pharmacology & Therapeutics (2012); 92 4, 443–445. doi: 10.1038/clpt.2012.119