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Clinical Translation of Cell‐Based Pharmacogenomic Discovery
Author(s) -
Cox N J,
Gamazon E R,
Wheeler H E,
Dolan M E
Publication year - 2012
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2012.115
Subject(s) - pharmacogenomics , computational biology , translation (biology) , drug discovery , translational research , biology , bioinformatics , genetics , gene , microbiology and biotechnology , messenger rna
The use of cell‐based models has emerged as a promising means to discover and validate pharmacologic phenotype–genotype relationships. The availability of large‐scale genome studies in both human and model systems is now allowing us an unprecedented opportunity to understand how well cell‐based models identify clinically relevant genetic variants associated with drug response and toxicity. Here we review these studies and the emerging translational information. Clinical Pharmacology & Therapeutics (2012); 92 4, 425–427. doi: 10.1038/clpt.2012.115