Nrf2: A Potential Target for New Therapeutics in Liver Disease

Nuclear erythroid 2–related factor 2 (Nrf2) is an oxidative stress–mediated transcription factor with a variety of downstream targets aimed at cytoprotection. Nrf2 has recently been implicated as a new therapeutic target for the treatment of liver disease. Here, we focus on the most common liver diseases—nonalcoholic fatty liver disease/steatohepatitis, alcoholic liver disease, and drug‐induced liver injury—and highlight areas in the development of these conditions where activation of Nrf2 may alleviate disease progression. Clinical Pharmacology & Therapeutics (2012); 92 3, 340–348. doi: 10.1038/clpt.2012.110