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Nrf2: A Potential Target for New Therapeutics in Liver Disease
Author(s) -
Bataille A M,
Manautou J E
Publication year - 2012
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2012.110
Subject(s) - liver disease , disease , medicine , intensive care medicine , pharmacology
Nuclear erythroid 2–related factor 2 (Nrf2) is an oxidative stress–mediated transcription factor with a variety of downstream targets aimed at cytoprotection. Nrf2 has recently been implicated as a new therapeutic target for the treatment of liver disease. Here, we focus on the most common liver diseases—nonalcoholic fatty liver disease/steatohepatitis, alcoholic liver disease, and drug‐induced liver injury—and highlight areas in the development of these conditions where activation of Nrf2 may alleviate disease progression. Clinical Pharmacology & Therapeutics (2012); 92 3, 340–348. doi: 10.1038/clpt.2012.110