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Obesity, the Metabolic Syndrome, and Sexual Dysfunction in Men
Author(s) -
Esposito K,
Giugliano D
Publication year - 2011
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2011.91
Subject(s) - erectile dysfunction , metabolic syndrome , obesity , endothelial dysfunction , proinflammatory cytokine , clinical pharmacology , medicine , testosterone (patch) , sexual dysfunction , endocrinology , nitric oxide , inflammation , pharmacology
Our understanding of the relationships between obesity, metabolic syndrome, and erectile dysfunction (ED) has advanced significantly over the past decades. Increase in visceral adiposity and related risk factors are associated with a proinflammatory state that results in decreased nitric oxide (NO) availability and activity that is responsible, at least in part, for endothelial injury and dysfunction as well as for ED. The reduced testosterone levels associated with obesity and metabolic syndrome may contribute to ED. Clinical Pharmacology & Therapeutics (2011) 90 1, 169–173. doi: 10.1038/clpt.2011.91