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New Drug Targets for the Treatment of Obesity
Author(s) -
Powell AG,
Apovian CM,
Aronne LJ
Publication year - 2011
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2011.82
Subject(s) - panacea (medicine) , obesity , intensive care medicine , medicine , management of obesity , drug development , clinical pharmacology , drug , energy homeostasis , pharmacology , bioinformatics , alternative medicine , weight loss , biology , pathology
There is a huge void in the current pharmacological treatment options for obesity. This gap is surprising given the high prevalence and associated costs of obesity. Many factors have prevented active drug development, including the poor safety and efficacy of earlier antiobesity drugs. However, there are now several compelling targets on the horizon. The new generation of antiobesity drugs offers hope for the management of obesity, but no single agent is likely to be a panacea. Rather, obesity will need to be managed like many other chronic diseases, with combination therapies and long‐term treatment in order to achieve sustained success. New targets have arisen as more research has been performed to understand the complex circuitry that controls energy homeostasis. The goal of this review is to discuss the latest pharmacological agents and strategies that are under development and that may eventually be used for the treatment of obesity. Clinical Pharmacology & Therapeutics (2011) 90 1, 40–51. doi: 10.1038/clpt.2011.82