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Adverse Drug Reactions In Utero : Perspectives on Teratogens and Strategies for the Future
Author(s) -
Mitchell AA
Publication year - 2011
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2011.52
Subject(s) - clinical pharmacology , thalidomide , drug reaction , medicine , drug , in utero , adverse effect , pharmacology , pregnancy , fetus , intensive care medicine , biology , multiple myeloma , genetics
Many think of an adverse drug reaction (ADR) as an adverse event caused by a medication intended for a given subject. However, as we learned from the thalidomide debacle 50 years ago, some of the most devastating ADRs affect not the subject who takes the medication but rather, in the case of pregnancy exposures, an innocent bystander—the fetus—and the ADRs include birth defects. Clinical Pharmacology & Therapeutics (2011) 89 6, 781–783. doi: 10.1038/clpt.2011.52