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Dermal Application of Nitric Oxide In Vivo : Kinetics, Biological Responses, and Therapeutic Potential in Humans
Author(s) -
Opländer C,
Römer A,
PaunelGörgülü A,
Fritsch T,
Faassen E E,
Mürtz M,
Bozkurt A,
Grieb G,
Fuchs Paul,
Pallua Norbert,
Suschek C V
Publication year - 2012
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2011.366
Subject(s) - in vivo , nitric oxide , vasodilation , hemodynamics , pharmacology , vasoactive , bioavailability , clinical pharmacology , blood flow , medicine , chemistry , cardiology , biology , microbiology and biotechnology
Many local hemodynamic and vascular disorders may be the result of impaired bioavailability of nitric oxide (NO). Previous findings point to a therapeutic potential of dermal NO application in the treatment of hemodynamic disorders, but no reliable data are available on the mechanisms, kinetics, or biological responses relating to cutaneous exposure to NO in humans in vivo . Here we show that, owing to its excellent diffusion capacity, cutaneously applied NO rapidly penetrates the epidermal barrier in significant amounts, strongly enriching skin tissue and blood plasma with its vasoactive derivates. In parallel, it significantly increased vasodilatation and blood flow and reduced thrombocyte aggregation capacity. Data presented here for the first time show that, in humans, dermal application of NO has strong potential for use in the therapy of local hemodynamic disorders arising from insufficient availability of NO or its bioactive derivates. Clinical Pharmacology & Therapeutics (2012); 91 6, 1074–1082. doi: 10.1038/clpt.2011.366