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The Epigenetic Code in Depression: Implications for Treatment
Author(s) -
Schroeder M,
Hillemacher T,
Bleich S,
Frieling H
Publication year - 2012
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.2011.282
Subject(s) - epigenetics , depression (economics) , major depressive disorder , medicine , psychiatry , epigenesis , bioinformatics , psychology , dna methylation , mood , biology , genetics , gene , economics , macroeconomics , gene expression
Major depressive disorder (MDD) is a common and disabling disorder that carries both a substantial personal burden as well as a social one. A better understanding of the epigenetic mechanisms in depression might provide a new framework for individually tailored pharmacologic treatment options. In this review we highlight current knowledge about the role of epigenetic mechanisms in the pathogenesis of depression and treatment implications.